Trintellix's interconnections with other medications, alcohol, and additional substances.
Intro
Trintellix's interconnections with other medications, alcohol, and additional substances.
Vortioxetine, sold under the brand name Trintellix, is a prescription medication used to manage major depressive disorder in adults. Just like other medications, Trintellix can interfere with certain drugs and supplements. This interference, known as an interaction, occurs when one substance alters another substance's intended effects.
For more info on Trintellix's drug interactions, stick around. For further details about its usage, check out this resource.
Avoiding Trintellix
Certain factors or conditions might prevent your doctor from prescribing Trintellix due to potential harm. These are known as contraindications. Trintellix's contraindications include:
Drug type or drug name
Using monoamine oxidase inhibitors (MAOIs)
Drug examples
If you've recently used an MAOI, discuss this with your physician or pharmacist before taking Trintellix. Like Trintellix, MAOIs are used to treat depression.
Interaction result with Trintellix
Using Trintellix along with an MAOI can increase the risk of a serious condition called serotonin syndrome. In serotonin syndrome, excessive levels of a chemical named serotonin accumulate in the body. This can lead to seizures and life-threatening complications.
Due to this risk, doctors usually won't prescribe Trintellix if you're on an MAOI or have used one within the past 14 days. Additionally, your doctor likely won't recommend beginning MAOI treatment within 21 days of ending Trintellix therapy.
monoamine oxidase inhibitors (MAOIs)
Examples of MAOIs include:
• methylene blue (Provayblue)• tranylcypromine (Parnate)• phenelzine (Nardil)
- methylene blue (Provayblue)
- tranylcypromine (Parnate)
- phenelzine (Nardil)
- linezolid (Zyvox)
- selegiline (Emsam)
- isocarboxazid (Marplan)
can increase the risk of side effects from both Trintellix* and MAOIs†
If you're using an MAOI, consult your doctor. They can help determine when it's safe to start Trintellix treatment.
Suffering from an allergic reaction to Trintellix or its components
selective serotonin reuptake inhibitors (SSRIs)
If you've experienced an allergic reaction to Trintellix or any of its constituents, your doctor probably won't prescribe Trintellix. Taking the medication could lead to another allergic reaction. You can ask your doctor about alternative treatments better suited to your situation.
• sertraline (Zoloft)• escitalopram (Lexapro)• fluoxetine (Prozac)• paroxetine (Paxil)
Note: Before starting Trintellix treatment, it's essential to inform your doctor if either of these contraindications applies to you. They can assess whether to prescribe Trintellix.
can increase the risk of side effects from both Trintellix* and SSRIs
Trintellix and alcohol interaction
Trintellix is not known to interact with alcohol.
serotonin-norepinephrine reuptake inhibitors (SNRIs)
Your physician may advise avoiding alcohol when taking Trintellix. This is because alcohol may boost the likelihood of Trintellix's side effects, such as:
• duloxetine (Cymbalta)• desvenlafaxine (Pristiq)• venlafaxine (Effexor XR)
- nausea
- vomiting
- increased risk of bleeding
can increase the risk of side effects from both Trintellix* and SNRIs
Since alcohol may also cause these side effects, combining alcohol and Trintellix might increase your risk even further.
If you wish to drink alcohol while taking Trintellix, discuss safe amounts with your doctor.
triptans
Trintellix interactions with other medications
• rizatriptan (Maxalt, Maxalt-MLT)• eletriptan (Relpax)• sumatriptan (Imitrex)
Before initiating Trintellix therapy, inform your doctor and pharmacist about all your prescription, over-the-counter, and other medications. Sharing this information with them can help prevent potential interactions.
can increase the risk of side effects from both Trintellix* and triptans
If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Here's a chart detailing drugs that can interfere with Trintellix. Bear in mind that this chart does not include all drugs that might interact with Trintellix. Some of these interactions are explored in more detail below in "Detailed drug interactions."
tricyclic antidepressants (TCAs)
Type or name of drugs | Examples | Effects on Trintellix interaction || --- | --- | --- || Inhibitors of monoamine oxidase (MAOIs) | methylene blue (Provayblue), tranylcypromine (Parnate), phenelzine (Nardil) | They could enhance the side effects from both Trintellix and MAOIs || Selective serotonin reuptake inhibitors (SSRIs) | sertraline (Zoloft), escitalopram (Lexapro), fluoxetine (Prozac), paroxetine (Paxil) | They might escalate the side effects from both Trintellix and SSRIs || serotonin-norepinephrine reuptake inhibitors (SNRIs) | duloxetine (Cymbalta), desvenlafaxine (Pristiq), venlafaxine (Effexor XR) | They could heighten the side effects from both Trintellix and SNRIs || Triptans | rizatriptan (Maxalt, Maxalt-MLT), eletriptan (Relpax), sumatriptan (Imitrex) | They might intensify the side effects from both Trintellix and triptans || Tricyclic antidepressants (TCAs) | amitriptyline, nortriptyline (Pamelor), doxepin (Silenor) | They could enhance the side effects from both Trintellix and TCAs || Nonsteroidal anti-inflammatory drugs (NSAIDs) | ibuprofen (Advil, Motrin), celecoxib (Celebrex), naproxen (Aleve, Naprosyn) | They might escalate the side effects from both Trintellix and NSAIDs || Certain pain medications | fentanyl (Actiq, Fentora, others), tramadol (ConZip), oxycodone (Oxaydo, Roxicodone, others) | They could augment the side effects from both Trintellix and certain pain medications || Certain treatments for attention deficit hyperactivity disorder (ADHD) | amphetamine salts (Adderall), methylphenidate (Concerta, Ritalin, others), lisdexamfetamine (Vyvanse) | They might escalate the side effects from both Trintellix and certain ADHD medications || CYP2D6 blockers | bupropion (Wellbutrin SR, Wellbutrin XL), fluoxetine (Prozac), quinidine | They could amplify the side effects from Trintellix || CYP2D6 inducers | rifampin (Rifadin, Rimactane), carbamazepine (Carbatrol, Tegretol, others), phenytoin (Dilantin, Phenytek) | They could diminish the effectiveness of Trintellix || Drugs that increase the risk of bleeding | aspirin, clopidogrel (Plavix), heparin, warfarin (Jantoven) | They might amplify the side effects from both Trintellix and drugs that increase the risk of bleeding || Diuretics | hydrochlorothiazide (Microzide), spironolactone (Aldactone, CaroSpir), furosemide (Lasix) | They could escalate the side effects from both Trintellix and diuretics || Ergotamines | dihydroergotamine (Migranal, Trudhesa), ergotamine/caffeine (Migergot), ergotamine tartrate (Ergomar), methylergonovine (Methergine) | They might amplify the side effects from both Trintellix and ergotamines || Lithium (Lithobid) | — | They could amplify the side effects from both Trintellix and lithium || Buspirone | — | They might amplify the side effects from both Trintellix and buspirone || Dextromethorphan (Delsym) | — | They could amplify the side effects from both Trintellix and dextromethorphan || Phentermine (Adipex-P, Lomaira) | — | They might amplify the side effects from both Trintellix and phentermine |
• amitriptyline• nortriptyline (Pamelor)• doxepin (Silenor)
Interaction outcome. Using Trintellix alongside certain medications, like SSRIs, can heighten the probability of serotonin toxicity*, which carries potential hazardous side effects. (Serotonin toxicity occurs when excessive serotonin builds up in your system. This could result in severe symptoms like seizures and other life-threatening complications.)
can increase the risk of side effects from both Trintellix* and TCAs
Interaction description. Trintellix and SSRIs both target your mood by boosting the presence of serotonin in your body. Combining agents that affect serotonin levels can escalate the likelihood of serious side effects, including serotonin toxicity.
Selections of SSRI drugs. Below is a list of commonly used SSRIs that can interact with Trintellix:
nonsteroidal anti-inflammatory drugs (NSAIDs)
- sertraline (Zoloft)
- escitalopram (Lexapro)
- fluoxetine (Prozac)
- paroxetine (Paxil)
• ibuprofen (Advil, Motrin)• celecoxib (Celebrex)• naproxen (Aleve, Naprosyn)
Procedures you or your physician may consider. Prior to initiating Trintellix treatment, inform your doctor about any SSRIs that you may be using. Depending on the situation, they might advise against the use of SSRIs alongside Trintellix. Your doctor will customize a treatment strategy tailored to your requirements.
can increase the risk of side effects from both Trintellix* and NSAIDs
However, if your doctor prescribes both Trintellix and an SSRI, they may monitor your condition more frequently for signs of serotonin toxicity. Keep an eye out for potential signs such as:
- agitation
- hallucinations
- sweating
- muscle spasms
certain pain medications
If you experience any of these symptoms, promptly reach out to your doctor or seek emergency medical attention.
• fentanyl (Actiq, Fentora, others)• tramadol (ConZip)• oxycodone (Oxaydo, Roxicodone, others)
CYP2D6 inducers
can increase the risk of side effects from both Trintellix* and certain pain medications
CYP2D6 inducers are varieties of medications used to manage various health conditions, such as seizures and infections.
Interaction outcome. Concurrent consumption of Trintellix and a CYP2D6 inducer can diminish Trintellix's effectiveness.
certain treatments for attention deficit hyperactivity disorder (ADHD)
Interaction details. Your body breaks down Trintellix using an enzyme (a protein) named CYP2D6. Certain medications can cause the CYP2D6 enzyme to work faster than usual. These medications are referred to as CYP2D6 inducers.
• amphetamine salts (Adderall)• methylphenidate (Concerta, Ritalin, others)• lisdexamfetamine (Vyvanse)
If you consume both Trintellix and a CYP2D6 inducer, the inducer might enhance the activity of CYP2D6. This could lead to a quicker breakdown of Trintellix, resulting in lower-than-usual drug levels. Consequently, the treatment might not be as effective as anticipated.
can increase the risk of side effects from both Trintellix* and certain ADHD medications
CYP2D6 inducer choices. Below are a few common CYP2D6 inducers that can potentially impact Trintellix:
- rifampin (Rifadin, Rimactane)
- carbamazepine (Carbatrol, Tegretol, others)
- phenytoin (Dilantin, Phenytek)
CYP2D6 blockers
Actions you or your doctor may take. Prior to commencing treatment with Trintellix, disclose any medications you are using to your physician or pharmacist. They can assess your current medications to identify any potential CYP2D6 inducers. In some instances, if you're on a CYP2D6 inducer, your doctor might prescribe a higher Trintellix dose. (To learn about the dosage of Trintellix, refer to this article.)
• bupropion (Wellbutrin SR, Wellbutrin XL)• fluoxetine (Prozac)• quinidine
Tricyclic antidepressants (TCAs)
can increase the risk of side effects from Trintellix*
Tricyclic antidepressants (TCAs) are frequently employed to manage depression.
Interaction outcome. Utilizing Trintellix alongside TCAs can augment the chance of serotonin toxicity.
CYP2D6 inducers
Interaction analysis. Trintellix can boost the levels of a chemical called serotonin within your body. TCAs can also enhance your serotonin levels. By simultaneously administering these medicines, you might further raise serotonin levels. When serotonin levels reach excessive proportions, serotonin toxicity can develop.
• rifampin (Rifadin, Rimactane)• carbamazepine (Carbatrol, Tegretol, others)• phenytoin (Dilantin, Phenytek)
Choices of TCA medications. Below are a few commonly used TCAs that interfere with Trintellix:
can reduce the effectiveness of Trintellix
- amitriptyline
- nortriptyline (Pamelor)
- doxepin (Silenor)
Procedures you or your doctor may implement. Prior to initiating Trintellix therapy, inform your doctor if you're taking any TCAs. Your physician will examine your current medications and support you in identifying any TCAs you are using. They are likely to recommend avoiding TCAs throughout your Trintellix treatment. An alternative treatment plan will be formulated for your situation.
drugs that increase the risk of bleeding
If your doctor prescribes both Trintellix and a TCA, they may monitor you more closely for signs of serotonin toxicity. Be vigilant for potential indicators, such as:
• aspirin• clopidogrel (Plavix)• heparin• warfarin (Jantoven)
- agitation
- hallucinations
- sweating
- muscle spasms
can increase the risk of side effects from both Trintellix* and drugs that increase the risk of bleeding
If you experience any of these symptoms, contact your doctor immediately or seek emergency medical help.
Further interactions involving Trintellix
diuretics
Trintellix might interact with other elements, such as supplements, food, vaccines, or even diagnostic tests. The following information provides insights, but it isn't exhaustive:
• hydrochlorothiazide (Microzide)• spironolactone (Aldactone, CaroSpir)• furosemide (Lasix)
Trintellix interactions with supplements
can increase the risk of side effects from both Trintellix* and diuretics
Before initiating Trintellix therapy, share a list of your current supplements, herbs, and vitamins with your physician and pharmacist. Such disclosure might help prevent potential interactions.
Certain supplements have the capability to elevate serotonin levels within your body. Trintellix can also elevate serotonin levels. By combining these supplements with Trintellix, you might augment serotonin levels further. If serotonin levels reach excessive proportions, serotonin toxicity can occur, leading to seizures and other life-threatening complications.
ergotamines
Examples of these supplements might include:
• dihydroergotamine (Migranal, Trudhesa)• ergotamine/caffeine (Migergot)• ergotamine tartrate (Ergomar)• methylergonovine (Methergine)
tryptophan5-hydroxytryptophan
can increase the risk of side effects from both Trintellix* and ergotamines
If you have queries about these supplements or any drug interactions that could affect you, consult your doctor or pharmacist.
Trintellix and herbal supplements
lithium (Lithobid)
Certain herbal supplements, like St. John’s wort, can increase your serotonin levels. Similar to Trintellix, St. John’s wort can increase serotonin levels. Therefore, combining it with Trintellix may further increase serotonin levels, potentially leading to serotonin syndrome, which could result in seizures and other life-threatening complications.
—
If you have doubts about the herbal supplements that you can take with Trintellix, discuss it with your doctor or pharmacist.
can increase the risk of side effects from both Trintellix* and lithium
Trintellix and vitamins
There aren't any specific reports of vitamins interfering with Trintellix. However, it's possible that vitamin interactions with Trintellix could be identified in the future. Consequently, it's advisable to talk with your doctor or pharmacist before consuming any vitamin product with Trintellix.
buspirone
Trintellix and food
—
There aren't any reports of food interactions with Trintellix. The drug isn't known to interact with any foods. Additionally, Trintellix shouldn't affect your appetite. If you'd like to learn more about eating certain foods during treatment with Trintellix, consult your doctor.
can increase the risk of side effects from both Trintellix* and buspirone
Trintellix and vaccines
There aren't any known interactions between Trintellix and vaccines. However, if you need to get any vaccines during your treatment with Trintellix, talk with your doctor or pharmacist. They can help ensure that none of your other medications interact with the vaccines.
dextromethorphan (Delsym)
Trintellix and lab tests
—
There aren't any known interactions between Trintellix and lab tests. However, if you need to have any lab tests done, discuss it with your doctor about any medications you take. They can help ensure that none of your other medications will interact with your lab tests.
can increase the risk of side effects from both Trintellix* and dextromethorphan
*TRINTELLIX INTERACTION WITH CANNABIS OR CBDCannabis* (commonly known as marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported** to interact with Trintellix. However, speak with your doctor before using cannabis in combination with Trintellix. The impact of cannabis may affect your adherence to your Trintellix treatment plan.
Note: Cannabis is illegal at a federal level but is legal in many U.S. states to varying degrees.
phentermine (Adipex-P, Lomaira)
Trintellix and health-related interactions
—
Certain medical conditions and other factors may increase the risk of interactions with Trintellix. Before you take this drug, discuss it with your doctor about your health history. Trintellix may not be the right treatment option if you have certain medical conditions or other factors affecting your health.
can increase the risk of side effects from both Trintellix* and phentermine
Health conditions or factors that might interact with Trintellix include:
Suicidal thoughts and behaviors. Disclose your history of mood problems, such as suicidal thoughts or behaviors, to your doctor before taking Trintellix. The drug carries a boxed warning about the risk of suicidal thoughts and behaviors in certain individuals. A boxed warning is a serious warning from the Food and Drug Administration (FDA). For more information, refer to “Boxed warning” at the beginning of this article.
Seizures or seizure disorders. Share your past history of seizures or if you have a current seizure disorder with your doctor. In rare cases, Trintellix could increase your risk of seizures. If you have this condition, your risk of experiencing this side effect may be higher.
You may also have an increased risk of seizures if you stop taking Trintellix abruptly. Discuss your Trintellix treatment options with your doctor.
Personal or family history of mood problems. If you have a personal or family history of mood problems other than depression, inform your doctor before starting Trintellix treatment. Also, tell them if a family member has had mood problems, including bipolar disorder. Trintellix could increase your risk of mood problems. Your doctor can help determine whether this medication is safe for you.
Glaucoma. Trintellix may cause or exacerbate glaucoma. If you already have glaucoma, taking Trintellix could worsen your condition. In such a case, your doctor can assist you in determining whether Trintellix is a suitable treatment option for you.
Low sodium levels in your blood. It's possible for Trintellix to lower sodium levels in your blood. If you already have low blood sodium levels, taking Trintellix may worsen your condition. Due to this risk, your doctor will likely manage your low sodium levels before starting you on Trintellix.
Bleeding problems. If you have any bleeding problems or bleeding disorders, such as hemophilia, inform your doctor before starting Trintellix treatment. This medication could increase your risk of bleeding, including serious bleeding in your digestive system. If you already have a bleeding disorder, your risk of experiencing this side effect may be higher. Your doctor can help determine whether Trintellix is safe for you.
Pregnancy. It's unclear if it's safe to use Trintellix during pregnancy. If you're pregnant or planning to be, consult with your physician to discuss whether it's safe for you to continue using Trintellix. (For more insights on Trintellix and pregnancy, refer to this resource.)
Breastfeeding. The safety of using Trintellix while breastfeeding is uncertain. At present, there's no information available on whether the drug gets excreted in breast milk or how it might affect a nursing infant. If you're breastfeeding, consult with your doctor prior to taking Trintellix.
Allergic reaction. If you've experienced an allergic response to Trintellix or its components, your doctor is likely to avoid prescribing Trintellix for you. You can discover more by reviewing "Reasons to avoid Trintellix" earlier in the text.
Get help when needed
If you or anybody you know is feeling suicidal or considering self-harm, seek help:
- Contact the 988 Suicide & Crisis Lifeline at 988 or visit 988lifeline.org for assistance from caring professionals round the clock, free of charge.
- Text "HOME" to the Crisis Text Line at 741741 to connect with a volunteer counselor for unconditional and cost-free support, available 24/7.
- If you're based outside the U.S., explore a helpline in your country through Befrienders Worldwide.
- In the U.S., dial 911 or your local emergency service number if you feel secure doing so.
If you're calling for help on behalf of someone else, stay nearby until help arrives. If it's safe to do so, remove objects or substances that could potentially harm them.
If you're not residing in the same household, remain on the phone until help is dispatched.
Frequently Asked Questions about Trintellix and possible interactions
Discover responses to some frequently asked questions about Trintellix and potential interactions.
Does Trintellix have an impact on sleep medications?
No, Trintellix usually doesn't interfere with sleep aids. If you're already using a sleep medication, it's likely safe to continue using it while undergoing Trintellix treatment.
Here are some common sleep medications that you might be able to take with Trintellix:
- zolpidem (Ambien)
- eszopiclone (Lunesta)
- ramelteon (Rozerem)
You should be aware that Trintellix could potentially cause sleep disturbances. These difficulties may stem from experiencing manic episodes (periods of high energy or excitement) or worsening depression or mood changes due to Trintellix treatment.
If you notice any changes in your sleep patterns while starting Trintellix therapy, discuss it with your doctor. They can help identify the cause and suggest potential remedies.
Are there any interactions between Trintellix and Viagra?
At present, no known interactions between Trintellix and sildenafil (Viagra) have been identified. However, Trintellix might increase your likelihood of developing sexual side effects. These could include:
- delayed ejaculation
- reduced libido (sex drive)
- problems achieving or sustaining an erection
If you experience sexual side effects throughout your use of Trintellix, your doctor might prescribe Viagra if you're a man. Chat with your doctor if you have any questions about the sexual side effects you might encounter from Trintellix or the best ways to manage them.
What antidepressant works efficiently with Trintellix?
Your doctor can help determine if another antidepressant would be a good match for Trintellix.
Generally, other antidepressants like selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs) aren't typically prescribed alongside Trintellix due to potential interactions. (Refer to the “Trintellix and other medications” section above for more details.)
Instead of antidepressants, your doctor might recommend taking Trintellix with certain antipsychotic medicines that are approved to treat depression. Examples of these drugs include lurasidone (Latuda), brexpiprazole (Rexulti), and aripiprazole (Abilify). Unlike TRINTELLIS, these medications have not been reported to interact with Trintellix.
Speak with your doctor or pharmacist to learn about which drugs are safe to use in conjunction with Trintellix.
- Let individuals know if you consume alcohol or use marijuana.
- Inform them about any other medicines you use, as well as any supplements, herbs, and vitamins.
- Prepare a , which your physician and pharmacist can assist you in completing.
It's equally crucial to review the Trintellix label and any additional literature that might accompany the drug. The label may contain warnings of potential interactions indicated by colored stickers. Additionally, the paperwork, sometimes referred to as the medication guide or patient package insert, may contain details about interactions. (If Trintellix doesn't include this paperwork, request a copy from your pharmacist.) If you have questions regarding this information, consult with your doctor or pharmacist.
You can also prevent interactions with Trintellix by adhering to the dosage prescribed by your physician.
Additional Resources
Beyond understanding potential interactions, you might be curious about Trintellix. These sources may provide further insight:
- Trintellix Fundamentals. For a general overview of Trintellix, check out this source.
- Side Effects. If you're interested in Trintellix's side effects, see this source. Alternatively, review the Trintellix prescribing information.
- Dosage Information. To learn about Trintellix's dosage, see this source.
- Drug Comparisons. To understand how Trintellix compares to Zoloft, Wellbutrin, Lexapro, and further medications, consult this source.
- Insights into Depression. To gather more information about your condition, visit our depression hub.
Disclaimer: Medical News Today has made every effort to ensure that all information is accurate, comprehensive, and up-to-date. However, this content should not replace the expertise of a licensed healthcare professional. Always consult your doctor or another healthcare professional before using any medication. The drug information contained within is subject to change and should not be considered a complete guide for all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The omission of warnings or other information for a given drug does not imply that the drug or drug combination is safe, effective, or appropriate for all patients or specific uses.
- Using Trintellix while taking monoamine oxidase inhibitors (MAOIs) can increase the risk of a severe condition called serotonin syndrome, which can lead to seizures and life-threatening complications.
- If a patient has an allergic reaction to Trintellix or its components, they might not be prescribed Trintellix due to the risk of another allergic reaction.
- Alcohol may boost the likelihood of Trintellix's side effects, such as nausea, vomiting, and increased risk of bleeding, when taken together.