Oral Bacteria and Fungi Linked to Pancreatic Cancer Risk
A groundbreaking study has found a link between certain oral bacteria and fungi, and an increased risk of pancreatic cancer. The research, led by Dr. Jennifer Smith, analysed saliva samples from over 122,000 adults over nearly nine years, with 445 participants developing the disease. Pancreatic cancer has a low five-year survival rate due to late diagnoses.
The study identified 27 bacterial and fungal species in the mouth associated with an increased risk of pancreatic cancer. Thirteen of these species, including three periodontal pathogens and the Candida genus, were found to heighten the risk. Conversely, eight species were linked to a decreased risk. A microbial risk score (MRS) based on these 27 species was developed for risk assessment.
An increase in MRS by one standard deviation was associated with a staggering 3.4-fold increased cancer risk. Additionally, oral Candida species were found in pancreatic tumors. While the study shows correlations, it does not establish causality, and further research is needed.
The study suggests that good oral hygiene may potentially protect against pancreatic cancer. However, more research is required to understand the relationship between oral microbes and pancreatic cancer. The findings offer a new avenue for potential early detection and prevention strategies, which could significantly improve outcomes for this devastating disease.
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