New Mouse Model Aids Bladder Cancer Study, Reveals Gender-Specific Insights
Uppsala University researchers, led by Dr. Anna-Karin Olsson, have developed a novel mouse model to study human bladder cancer progression. Published in PLOS ONE, the model mirrors human tumour growth and immune response, offering insights into gender-specific treatment strategies.
The model, created using single-cell sequencing, mimics human bladder cancer development with a high incidence of harmful mutations. It contains specific oncogenes and allows researchers to study tumour development in both males and females, as well as their response to various treatments.
Dr. Olsson and her team studied protein changes in blood and urine during tumour development and after muscle invasion. They noted a gender difference in early-stage bladder cancer and response to immunotherapy. The model may help improve understanding of immune cell infiltration and designing gender-specific treatment strategies.
Funded by the Swedish Cancer Society, the Swedish Society for Medical Research, and the European Social Fund, this research offers a promising tool for bladder cancer study. The new mouse model, with its human-like immune system and tumour growth, could significantly enhance our understanding of the disease and aid in developing targeted, gender-specific treatments.
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