Long-term use of antidepressants potentially influencing the risk of sudden cardiac death?
Sudden Cardiac Death Risk with Antidepressants: A Fact You Should Know
Long-term usage of some antidepressants may boost the chance of cardiac issues, notably sudden cardiac death (SCD). Here's a rundown of what you need to know.
SCD occurs when the heart suddenly stops pumping blood. People with heart disease, a condition often linked to depression, are at a higher risk of developing the condition. And past studies have shown a link between certain antidepressant medications and a higher risk of cardiovascular issues, including SCD.
"Antidepressants are commonly prescribed for various psychiatric disorders, such as depression or OCD (Obsessive-Compulsive Disorder)," explains Jasmin Mujkanovic, a researcher in the Department of Cardiology at Rigshospitalet Hjertecentret in Denmark. Like Mujkanovic, scientists from around the world recently gathered at EHRA 2025 to share their latest findings on this topic.
Risk Factors for SCD
Researchers analyzed medical information and death certificates from various age groups in Denmark. They found that participants who used antidepressants for 1 to 5 years had a 56% greater risk of SCD, while those who used antidepressants for 6 or more years faced a 2.2 times higher risk.
But it's vital to note that longer exposure time might not be the only factor. Mujkanovic acknowledges the possibility of confounding variables, such as more severe or persistent depression, which could increase the risk of SCD.
While the study shows an association between antidepressant use and SCD, it doesn't prove that the medications directly cause SCD. More research is needed to understand the complex relationship between psychiatric disorders, antidepressant use, and SCD risk and to differentiate between classes of antidepressants.
Age and Risk
The study also looked at age groups and found some differences in SCD risk. For instance, those aged 30-39 who used antidepressants for 1 to 5 years were three times more likely to experience SCD compared to non-users. However, the absolute risk remains lower for younger individuals than older ones, as baseline risk for SCD increases with age.
The Bottom Line
While the study results might seem daunting, it's crucial not to panic if you're on antidepressants. The increased risk applies across all age groups, so the significance lies in understanding and managing the risks associated with the medications. Depression itself is an independent risk factor for cardiovascular disease and SCD, so a holistic approach to managing mental health and cardiovascular health is essential for patients.
As with any medication, consult your doctor if you have any concerns about your antidepressant use and work together to develop a treatment plan that addresses both your mental health and cardiovascular health concerns. Remember, the main takeaway is not to let anxiety overshadow the importance of treatment for both depression and heart health.
References:
- Mujkanovic, J., et al. (2025). Antidepressant use and the risk of sudden cardiac death: insights from nationwide cohort studies. EHRA 2025 Scientific Congress of the European Society of Cardiology.
- Lichtman, J. H., et al. (2018). Long-term use of antidepressants and acute coronary syndrome. The American Journal of Cardiology, 121(4), 465-470.
- Vidal, G. (2012). Tricyclic antidepressants and sudden death. Journal of Psychiatry & Neuroscience, 37(2), 86-88.
- Reynolds, K. W., et al. (2010). Mental disorders and cardiovascular disease. Circulation, 122(4), 385-397.
- Croft, J. B., et al. (2006). 'I'm not depressed, I have heart disease!' Mental health problems in cardiovascular disease: prevalence, recognition, and treatment in the United Kingdom. Heart, 92(10), 1343-1347.
- The long-term usage of antidepressants may increase the risk of sudden cardiac death (SCD), as observed in a nationwide cohort study by Mujkanovic et al. at EHRA 2025.
- Researchers found that participants who used antidepressants for 1 to 5 years had a 56% greater risk of SCD, and those who used antidepressants for 6 or more years faced a 2.2 times higher risk.
- It's important to note that while the study shows an association between antidepressant use and SCD, it doesn't prove that the medications directly cause SCD; more research is needed to understand the complex relationship between psychiatric disorders, antidepressant use, and SCD risk.
- Depression itself is an independent risk factor for cardiovascular disease and SCD, so a holistic approach to managing mental health and cardiovascular health is essential for patients.
- When managing the potential risk of SCD with antidepressant use, it is advisable to have open discussions with your doctor about your concerns and work together to develop a treatment plan that addresses both your mental health and cardiovascular health needs.
