Jakafi Dosage Details: Strengths, Forms, Methods of Administration, and Additional Information
Jakafi, a brand-name drug, is used to treat graft-versus-host disease (GVHD) and other blood conditions. This medication belongs to the drug class called kinase inhibitors [1]. It's essential to follow your doctor's directions for taking Jakafi, and never change your dosage without their recommendation.
Dosage for Adults
The recommended dosage of Jakafi varies depending on the condition and patient age. For myelofibrosis and polycythemia vera, the typical starting dose is 20 mg orally twice daily for adults, though exact dosing may vary based on patient factors such as platelet counts and response [1][2].
For acute GVHD, the recommended dosage is 5 mg twice per day, which may be increased to 10 mg twice per day after 3 days of treatment [3]. In cases involving strong CYP3A4 inhibitors, the recommended starting dose for myelofibrosis is typically reduced to 10 mg twice daily to avoid toxicity [5].
For chronic GVHD in adults, the recommended dosage is 10 mg twice per day [2].
Dosage for Pediatric Patients (12 years and older)
Jakafi is FDA-approved for acute and chronic GVHD in pediatric patients aged 12 and older. Exact dosing depends on weight and disease severity [2].
Variation with Age and Condition
Dose adjustments are often required for interactions (e.g., with CYP3A4 inhibitors), liver function, and cytopenias. Pediatric dosing is restricted to 12 years and older for GVHD indications; data for younger children or other conditions are not specified [1][2][5].
Special Considerations
If you have trouble swallowing tablets, you can find tips on how to take this form of medication in an article or by talking with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If you're having trouble opening medication bottles, ask your pharmacist about putting Jakafi in an easy-open container.
It's important to note that Jakafi is not available in a generic version. Always follow the dosage that your doctor prescribes. If you miss a dose of Jakafi, take your next scheduled dose at the regular time. Do not take two doses to make up for the missed one.
If you take certain medications known as CYP3A4 inhibitors, your doctor may recommend a lower Jakafi dosage. If you have certain changes in blood cell counts, your doctor may also recommend a lower Jakafi dosage.
In case of an overdose, call your doctor right away.
Jakafi may be taken as a long-term treatment, depending on the condition being treated.
[1] - [National Library of Medicine] (https://pubmed.ncbi.nlm.nih.gov/29218738/)
[2] - [FDA] (https://www.fda.gov/drugs/information-drug-class/ruxolitinib-inhibitors-janus-associated-kinase-2-jak2-and-janus-associated-kinase-3-jak3)
[3] - [American Society of Haematology] (https://asheducation.org/journal/ash-educational-book/hematopoietic-cell-transplantation/post-transplant-complications/graft-versus-host-disease/graft-versus-host-disease-acute-and-chronic/)
[5] - [Mayo Clinic] (https://www.mayoclinic.org/drugs-supplements/ruxolitinib-oral-route/precautions/drg-20072431)
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