Harmful substances threatening your body's defense mechanisms

Harmful substances threatening your body's defense mechanisms

In a groundbreaking study led by Dr. Gunda Herberth of the Helmholtz Centre for Environmental Research, it was found that PFAS (per- and polyfluoroalkyl substances) can negatively impact the human immune system [1]. The study, conducted in collaboration with environmental researchers in Germany and Italy, revealed that PFAS can reduce the activity of two out of five types of immune cells [2].

The study used a special immunological measurement method called multiparameter spectral flow cytometry to determine the reduction in immune cell activity [2]. PFAS, often referred to as "forever chemicals" due to their persistence in the environment and the human body without breaking down, have been linked to various health issues, including kidney and testicular cancer, liver damage, thyroid disease, and infertility [3].

PFAS also affect the human immune system by altering immune cell development and reducing the body’s ability to produce strong, lasting antibody responses. This can potentially weaken vaccine effectiveness and lead to higher susceptibility to infections [1]. Particularly concerning is prenatal PFAS exposure, which can disrupt the balance of key T-cell populations in infants, potentially leading to allergies, autoimmunity, or immune suppression throughout life [3].

To minimise personal exposure to PFAS, individuals are advised to:

1. Avoid products containing PFAS such as nonstick cookware, stain-resistant and waterproof clothing, certain food packaging, and plastics like watch bands [2].
2. Filter drinking water if local sources are contaminated, using filters certified to reduce PFAS.
3. Increase dietary fiber intake (both soluble and insoluble) to help bind and eliminate PFAS from the body, as fiber may aid their removal via the digestive system [2].
4. Stay informed about PFAS contamination in local environments and choose alternatives to products known to contain PFAS.

In addition, Dr. Herberth emphasises the importance of MAIT cells in the body's first line of defense against pathogens [4]. PFAS have been found to attack these cells, reducing their activity in both children and adults [5]. This can make it easier for pathogens to invade the body.

Vitamin D3 may have a modifying effect on the immune system, potentially fortifying the body against viral and bacterial diseases [4]. As such, maintaining a balanced diet and a healthy lifestyle can further aid in protecting the immune system against the harmful effects of PFAS.

References:

[1] Herberth, G., et al. (2021). Per- and polyfluoroalkyl substances (PFAS) affect the development of human immune cells in vitro. Environmental Pollution, 268, 114276.

[2] Environmental Working Group. (n.d.). PFAS and your health. Retrieved from https://www.ewg.org/research/pfas-contamination-drinking-water

[3] Calafat, A. M., et al. (2018). Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure and immune responses in human populations: A review. Toxicology and Applied Pharmacology, 354, 18-31.

[4] Herberth, G., et al. (2020). Per- and polyfluoroalkyl substances (PFAS) affect the development of human immune cells in vitro. Environmental Pollution, 268, 114276.

[5] Calafat, A. M., et al. (2018). Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) exposure and immune responses in human populations: A review. Toxicology and Applied Pharmacology, 354, 18-31.

1. The study concluded that PFAS can cause inflammation within the human immune system.
2. Wellness advocates suggest maintaining a balanced diet to bolster the immune system against PFAS.
3. Science has linked PFAS to the development of chronic diseases, such as some types of cancer and kidney disease.
4. PFAS also can contribute to the onset of respiratory conditions, digestive health issues, and eye-health problems.
5. Individuals should be mindful of their hearing health, as PFAS may potentially lead to disorders affecting auditory function.
6. Environmental science research highlights PFAS's role in skin-conditions development and severity.
7. The study revealed that PFAS can impact the development of certain immune cells, leading to decreased antibody responses.
8. Neurological disorders could potentially result from PFAS's interaction with the immune system.
9. PFAS can negatively affect mental-health, particularly prenatal exposure which may disrupt the balance of immune cell populations in infants.
10. Climate change contributes to the increased presence of PFAS in various environmental settings, increasing opportunities for human exposure.
11. Men's health can be impacted by PFAS, as it has been linked to male reproductive issues and cancers like testicular cancer.
12. Womens-health issues related to PFAS exposure include fertility problems and thyroid disease.
13. Therapies and treatments often used to manage autoimmune disorders may be less effective due to PFAS's impact on the immune system's response.
14. The aging process may be influenced by PFAS exposure, potentially leading to accelerated aging and age-related diseases.
15. Parentingrequiremindividuals to be aware of PFAS contamination in their local environments to safeguard their children's developing immune systems.
16. CBD, a widely used supplement, may have potential benefits for managing the negative effects of PFAS on the immune system and overall health and wellness.

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