Genetic Study Reveals Sex Differences in Depression Risk
A groundbreaking global study has shed new light on the genetic factors contributing to depression, revealing significant differences between males and females. The research, involving over 195,000 participants, found that females carry a higher genetic risk of major depression and have distinct genetic influences compared to males.
The study, led by an international team of scholars, analysed the DNA of about 130,000 females and 65,000 males diagnosed with depression. It discovered that around 7,000 genetic changes could cause depression in both sexes, but an additional 6,000 were found exclusively in females. This means that females carry about twice as many genetic 'flags' for depression as males.
The findings challenge traditional approaches to depression research and treatment. Historically, most drug trials and therapies have been tested predominantly on males. However, this study underscores the importance of considering sex-specific genetic influences in studying and treating depression. It is the first to reveal the genetic reasons behind females' higher likelihood of depression.
The study's results, which are publicly available for further analysis, highlight the need for more research into sex-specific genetic influences in depression. This could lead to more effective, tailored treatments for both males and females. The findings also underscore the importance of diversity in clinical trials to ensure that treatments work for everyone.
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