Dosage Information for Mavyret: Varieties, Potencies, Administration, and Further Details
Mavyret, a brand-name prescription medication, is approved by the Food and Drug Administration (FDA) to treat certain types of hepatitis C virus (HCV) in adults and children aged 3 years and older [1]. This direct-acting antiviral medication comes as an oral tablet or pellet, containing the two active drugs glecaprevir and pibrentasvir [2].
In adults, the typical dosage for treatment-naïve patients without cirrhosis is three tablets orally once daily with food for 8 weeks [5]. For patients with compensated cirrhosis (Child-Turcotte-Pugh class A), the treatment duration may extend up to 12 to 16 weeks, depending on prior treatment history and viral genotype [1][3][5].
For treatment-experienced adults, especially those who have previously received NS5A inhibitors but not NS3/4A protease inhibitors, Mavyret is typically given as three tablets once daily with food for 16 weeks [3]. However, for patients with decompensated cirrhosis (Child-Pugh B or C), Mavyret is generally not recommended due to safety concerns; alternative regimens are preferred [3][5].
For children aged 3 to under 12 years, dosing is weight-based using packets or pellets. Those weighing 20 to less than 30 kg receive four packets once daily, totaling 200 mg glecaprevir and 80 mg pibrentasvir, for 8 to 16 weeks if they do not have cirrhosis [1]. Children weighing 30 to less than 45 kg receive five packets once daily (250 mg glecaprevir and 100 mg pibrentasvir) for 8 to 16 weeks if no cirrhosis, or 12 to 16 weeks if they have cirrhosis [1]. Dose adjustments for cirrhosis in children follow similar duration extensions as adults but should be determined by a physician [1].
It's essential to take Mavyret with food to optimize absorption, and no dose adjustment is needed based on renal function [5]. This dosing structure ensures effective treatment tailored by age, weight, liver status, and prior therapy exposure [1][3][5].
Remember, never use more Mavyret than prescribed by your doctor, as it may lead to side effects or overdose. If you believe you've taken too much Mavyret, call your doctor right away or the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room [4].
Mavyret oral pellets are typically prescribed to children and should not be crushed or chewed. If a dose of Mavyret is missed and it's more than 18 hours from the scheduled time, skip the missed dose and take the next dose at the usual time. If it's less than 18 hours, take the dose as soon as remembered and continue with the usual dosing schedule [4].
For people who have trouble reading prescription labels, there are options like labels with large print, braille, or a code that converts text to speech. If you have trouble opening tablet medication bottles, ask your pharmacist about putting Mavyret in an easy-open container or tools that make it easier to open bottles and unit dose packets [6].
In summary, Mavyret offers a tailored treatment approach for various patient groups, ensuring effective management of HCV in both adults and children. Always consult your healthcare provider for personalised advice and guidance.
| Patient Group | Dose & Form | Duration | Notes | |-----------------------------------------------|-------------------------|--------------------|------------------------------------------| | Adults, treatment-naïve, no cirrhosis | 3 tablets orally daily | 8 weeks | With food | | Adults, compensated cirrhosis or prior treatment | 3 tablets daily | 12–16 weeks | Extended duration for cirrhosis/experience | | Adults, decompensated cirrhosis | Not recommended | N/A | Alternative regimens preferred | | Children 20–<30 kg | 4 packets once daily | 8–16 weeks | Pellets, weight-based dosing | | Children 30–<45 kg | 5 packets once daily | 8–16 weeks (no cirrhosis), 12–16 weeks (cirrhosis) | Weight-based, physician-determined |
- The science behind Mavyret, a treatment for certain types of hepatitis C, involves direct-acting antiviral therapies and health-and-wellness approaches that are specifically tailored to the liver health of the patient, considering factors like disease progression, alcohol use, and prior treatments.
- For adults with no cirrhosis and no prior treatment history, Mavyret therapy involves taking three tablets orally once daily with food for a duration of 8 weeks, while those with compensated cirrhosis may need to extend the treatment up to 12 to 16 weeks, depending on distinct factors like prior treatment history and viral genotype.
- In the case of alcohol use, it's crucial to remember that Mavyret therapy and overall liver health can be influenced by alcohol consumption, making it vital for patients to discuss their alcohol use with healthcare providers to ensure the most effective therapies-and-treatments for their specific health situation.
