Breakthrough Peptide CAQK Shows Promise in Treating Traumatic Brain Injury
A groundbreaking study has found a small peptide, CAQK, to significantly improve functional recovery in mice with traumatic brain injury (TBI). The discovery, published in EMBO Molecular Medicine, opens new avenues for treating TBI, which affects around 200 people per 100,000 inhabitants each year, with no approved drugs currently available.
CAQK, composed of four amino acids, specifically targets injured brain areas, attracted by a protein overexpressed in damaged tissue. When injected intravenously, it travels directly to the affected region, reducing inflammation, cell death, and tissue damage. Treated animals displayed improved memory and motor function, with no signs of toxicity.
The potential of CAQK has not gone unnoticed. Aivocode, a company founded by researchers involved in the study, plans to soon seek authorization from the U.S. Food and Drug Administration (FDA) to begin Phase I clinical trials in humans. This marks a significant step towards drug-based treatments for TBI.
The successful preclinical results with CAQK pave the way for human clinical trials, which could revolutionize the treatment of TBI. While details about the timeline and specifics of the human trials are yet to be announced, this development offers hope for those affected by this devastating condition.
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