Amycretin pill potentially offers greater weight loss efficiency compared to semaglutide.
New Weight Loss Drug Amycretin Shows Promising Results
Amycretin, a next-generation unimolecular dual agonist developed by Novo Nordisk, is making waves in the weight loss industry with its promising early results. This innovative drug targets both the GLP-1 receptor and the amylin receptor simultaneously, combining the effects of GLP-1 receptor agonism with amylin receptor agonism.
In a phase 1 clinical trial, Amycretin led to a 13% reduction in body weight over a 3-month period. This is a significant improvement compared to previous trials with semaglutide, which resulted in an approximate 6% reduction in body weight over a similar timeframe.
Dr. Jared Ross, a professor and medical director, explained that Amycretin is an analog to amylin, a hormone secreted by the pancreas, and represents the first oral hormonal medication for obesity. The oral administration of Amycretin is more appealing to patients compared to the injectable medications like Ozempic and Wegovy.
The dual mechanism of Amycretin—engaging both GLP-1 and amylin pathways—may enhance efficacy without increasing aversive side effects, such as nausea, improving tolerability and adherence.
Dr. Mir Ali, a bariatric surgeon, agreed that the development of Amycretin is exciting news, but emphasized that more research is needed to examine long-term side effects and effectiveness. Dr. Simon C. Cork, a senior lecturer at Anglia Ruskin University, expressed excitement about the results of the Amycretin study, but cautioned that peer-reviewed published clinical trials are needed to confirm its effectiveness compared to other drugs.
Novo Nordisk intends to initiate a comprehensive development program based on the findings of the phase 1 trial for Amycretin. The company anticipates the results of a study on an injectable version of Amycretin to be released next year.
Amycretin's potential advantages over current GLP-1 agonists like Ozempic, Wegovy, Mounjaro, and Zepbound include faster and more substantial weight loss, potentially fewer aversive side effects, and extended patent protection and pricing.
Despite promising initial data, Amycretin remains in clinical trials (Phase 2/3), so final safety, tolerability, and real-world effectiveness data are pending. These will be critical to confirm its advantages over established medications.
In summary, Amycretin’s dual GLP-1/amylin receptor agonism represents a next-generation weight loss therapy that may provide greater and faster weight reduction with better tolerability compared to existing GLP-1 agonist drugs such as Ozempic, Wegovy, Mounjaro, and Zepbound by leveraging complementary hormone pathways to control appetite and metabolic effects.
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