Alzheimer's Breakthrough: First Molecular Map Reveals Disease Onset
Scientists have made a groundbreaking discovery in Alzheimer's research. They've created the first comprehensive molecular map, revealing how the disease begins in the human brain. This challenges the traditional view of amyloid beta proteins and opens new avenues for prevention and treatment.
Amyloid beta proteins, once considered solely harmful, now show varying effects depending on molecular contexts. They naturally exist in every brain, but aggregation into larger structures forms the plaques found in Alzheimer's patients.
The study, led by Prof. Bading at the International Neuroscience Center (IZN), analyzed over 140,000 protein variants. It identified precise molecular events triggering toxic plaque formation. High-throughput techniques allowed for simultaneous analysis of tens of thousands of variants, uncovering patterns missed by studying individual mutations.
The research team discovered a key protein-protein complex, 'TwinF,' that plays a central role in cognitive decline. They developed FP802, a 'TwinF Interface Inhibitor,' which significantly slowed disease progression in an Alzheimer's mouse model.
The molecular map provides a roadmap for early intervention, targeting nucleation events rather than later plaque formation. Subtle molecular differences explain why some people develop Alzheimer's while others with similar risk factors remain healthy. This breakthrough brings us closer to understanding and treating this devastating disease.
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