Alcohol, Supplement Consumption, and Beyond: Insights into Camzyos' Habits
Base Article:
Camzyos, also known as mavacamten, is a prescription medication in capsule form for treating obstructive hypertrophic cardiomyopathy. It can interact with some other drugs and certain supplements, and it is vital to be aware of these interactions.
To better understand these interactions, let's explore what an interaction is and focus on Camzyos's interactions with other medications.
Camzyos interactions with other medications
Camzyos can have interactions with drugs that affect the action of certain enzymes in your body, specifically enzymes like CYP3A4 and CYP2C19. These enzymes play a role in clearing Camzyos from your system.
Camzyos can interact with drugs that inhibit (reduce the action of) or induce (increase the action of) these enzymes. It can also react with other drugs that are broken down by these enzymes.
strong CYP3A4 inhibitors*
To minimize the risk of drug interactions, it's essential to inform your doctor and pharmacist about all the prescription, over-the-counter, and any other medications you are taking before starting Camzyos treatment. By sharing this information, you can help prevent potential interactions.
• clarithromycin• itraconazole (Sporanox)• ritonavir (Norvir)• nefazodone
The following table lists common drug groups and examples of drugs that can interact with Camzyos:
can increase the risk of side effects of Camzyos
| Drug group or drug name | Drug examples | Interaction result with Camzyos ||-------------------------------|---------------------|-------------------------------------------------------------------------|| strong CYP3A4 inhibitors | clarithromycin, | can increase the risk of side effects of Camzyos || | itraconazole | || | ritonavir | || | nefazodone | || strong or moderate CYP2C19 | cimetidine | can increase the risk of side effects of Camzyos || inhibitors | esomeprazole | || | fluconazole | || | fluoxetine | || strong or moderate CYP3A4 | carbamazepine | can make Camzyos less effective || inducers | phenytoin | || | rifampin | || strong or moderate CYP2C19 | apalutamide | can make Camzyos less effective || inducers | efavirenz | || | enzalutamide | || moderate CYP3A4 inhibitors | amiodarone | can increase the risk of side effects of Camzyos || | ciprofloxacin | || | erythromycin | || | danazol | || weak CYP2C19 inhibitors | nicardipine | can increase the risk of side effects of Camzyos || | omeprazole | || | oxcarbazepine | || certain heart medications | beta-blockers | can increase the risk of side effects of Camzyos || | diltiazem | || | disopyramide | || | ranolazine | || | verapamil | || combined birth control pills | ethinyl estradiol | can make combined birth control pills less effective || | desogestrel | || | drospirenone | || drugs that are broken down | glipizide | by CYP3A4, CYP2C19, and CYP2C9 || by CYP3A4, CYP2C19, and CYP2C9 | midazolam | || | repaglinide | |
For more details about drug interactions, consult your doctor or pharmacist. To learn about potential interactions with supplements, herbs, or vitamins, read the "Camzyos and Other Interactions" section below.
strong or moderate CYP2C19 inhibitors*
Avoiding Camzyos
• cimetidine (Tagamet HB)• esomeprazole (Nexium)• fluconazole (Diflucan)• fluoxetine (Prozac)
Contraindications
can increase the risk of side effects of Camzyos
There are certain situations where your doctor might choose not to prescribe Camzyos. These are known as contraindications. Camzyos has the following contraindications:
Taking drugs that affect certain enzymes
strong or moderate CYP3A4 inducers*
Your doctor will typically not prescribe Camzyos with drugs that inhibit (reduce the action of) CYP3A4 and CYP2C19, as these enzymes play a role in clearing Camzyos from your body. Taking Camzyos with drugs that inhibit these enzymes can lead to Camzyos levels building up in your body, increasing the risk of serious side effects like heart failure.
• carbamazepine (Tegretol, others)• phenytoin (Dilantin)• rifampin (Rifadin, Rimactane)
Here's a list of drugs commonly prescribed for conditions like seizures, fungal infections, HIV, depression, and acid reflux that can potentially interact with Camzyos:
can make Camzyos less effective
- certain seizure medications, e.g., cenobamate, felbamate, and ritonavir
- certain antifungals, e.g., fluconazole, ketoconazole, itraconazole, and voriconazole
- certain HIV drugs, e.g., cobicistat, nelfinavir, and ritonavir
- certain antidepressants, e.g., fluoxetine, fluvoxamine, and nefazodone
- certain drugs for excess stomach acid, e.g., cimetidine, esomeprazole, and clarithromycin
- the blood thinner ticlopidine
View the "Camzyos Interactions with Other Medications" section for more information.
strong or moderate CYP2C19 inducers*
When to avoid Camzyos
• apalutamide (Erleada)• efavirenz• enzalutamide (Xtandi)
In some cases, factors or conditions could prevent your doctor from prescribing Camzyos, posing a risk of harm. This is particularly true for:
can make Camzyos less effective
Having had an allergic reaction to Camzyos
If you have ever had an allergic reaction to Camzyos or any of its ingredients, your doctor will likely not prescribe the drug to you, as it could result in another allergic reaction. In such a situation, you should discuss alternative treatments with your doctor.
moderate CYP3A4 inhibitors
Interaction with alcohol
• amiodarone (Pacerone)• ciprofloxacin (Cipro)• erythromycin (Erytab, others)• danazol
There's no known interaction between Camzyos and alcohol. However, your doctor may advise you to avoid or reduce alcohol consumption while taking Camzyos as it may worsen some side effects, like dizziness. Drinking alcohol may also exacerbate dizziness caused by obstructive hypertrophic cardiomyopathy, for which Camzyos is used to treat. If you have questions about consuming alcohol while taking Camzyos, speak with your doctor.
can increase the risk of side effects of Camzyos
For more information on drug interactions, visit Camzyos interactions with other medications.
Drug interactions in depth
weak CYP2C19 inhibitors
For a closer look at drug interactions with Camzyos, refer to the sections below:
• nicardipine• omeprazole (Prilosec) • oxcarbazepine (Trileptal)
- Certain heart medications
- Combined birth control pills
- Omeprazole (Prilosec)
can increase the risk of side effects of Camzyos
Camzyos and other interactions
Camzyos interactions with supplements
certain heart medications
Before starting treatment with Camzyos, inform your doctor and pharmacist about all supplements, herbs, and vitamins you take. Sharing this information can help prevent potential interactions.
• beta-blockers, such as metoprolol (Lopressor)• diltiazem (Cardizem CD, others)• disopyramide (Norpace)• ranolazine (Aspruzyo sprinkle)• verapamil (Verelan)
If you have questions about drug interactions that may affect you, consult your doctor or pharmacist.
can increase the risk of side effects of Camzyos
Camzyos interactions with herbs
Doctors typically advise avoiding St. John's wort while taking Camzyos, as it may interfere with the drug's metabolism. St. John's wort may speed up the activity of the enzyme CYP3A4, which is responsible for breaking down Camzyos. This may lead to reduced levels of Camzyos in your body, potentially making it less effective at treating your heart condition. Your doctor may be able to suggest alternative treatments if you're using St. John's wort.
combined birth control pills
Camzyos and vitamins
• ethinyl estradiol/desogestrel (Cyclessa, others)• ethinyl estradiol/drospirenone (Yaz)
While there are no specific reports of vitamins interacting with Camzyos, consult your doctor or pharmacist before taking any vitamin product with Camzyos to avoid potential interactions.
can make combined birth control pills less effective
Camzyos interactions with food
Grapefruit and grapefruit juice may interact with Camzyos. Specifically, grapefruit products can prevent your body from breaking down Camzyos, causing higher levels of Camzyos in your body and increasing the risk of side effects. Your doctor may recommend avoiding grapefruit and grapefruit juice while taking the drug.
drugs that are broken down by CYP3A4, CYP2C19, and CYP2C9
Camzyos and vaccines
• glipizide (Glucotrol XL)• midazolam (Nayzilam, Seizalam)• repaglinide
There's no known interaction between Camzyos and vaccines. Consult your doctor or pharmacist to determine whether you're due for any vaccines.
can make drugs broken down by CYP3A4, CYP2C19, and CYP2C9 less effective
Camzyos and lab tests
Camzyos is not known to interact with any lab tests. If you have concerns about this medication interacting with lab tests, contact your doctor.
Camzyos and health-related interactions
Certain medical conditions and factors may increase the risk of interactions with Camzyos. Before taking this drug, discuss your health history with your doctor. It's important to recognize that Camzyos may not be suitable for everyone, as it can have potential risks and challenges in certain situations.
Possible interactions include:
- Heart failure: Camzyos has a boxed warning regarding the risk of heart failure in some individuals. Be sure to discuss this with your doctor.
- Serious infection: A serious infection may increase the risk of heart failure. Inform your doctor if you have a serious infection before or during Camzyos treatment.
- Irregular heartbeat: An irregular heartbeat may increase the risk of heart failure. Discuss your heartbeat history with your doctor before starting Camzyos treatment.
- Allergic reaction: If you've ever had an allergic reaction to Camzyos or any of its ingredients, your doctor will likely not prescribe it. Consult your doctor about alternative treatments if this applies to you.
- Breastfeeding: Talk to your doctor before using Camzyos while breastfeeding, as it's not yet clear whether the drug passes into breast milk or has any effects on a nursing child.
- Pregnancy: There haven't been enough clinical trials to determine whether Camzyos is safe to take during pregnancy. Consult your doctor if you're pregnant or planning to become pregnant before starting Camzyos treatment.
For more information, view Camzyos and health-related interactions.
- In the realm of science and medical-conditions, genetics plays a significant role in understanding drug interactions, such as those related to Camzyos.
- The pharmacology of Camzyos is intricate, as it interacts with drugs that impact certain enzymes like CYP3A4 and CYP2C19, which clear the drug from the body.
- When it comes to cardiovascular health and medications like Camzyos, other drugs that inhibit or induce these enzymes can have profound effects on the heart and disease, increasing the risk of side effects.
- In the context of health-and-wellness, it's crucial to be aware of other genetic factors and potential interactions that may impact the efficacy of medication, such as Camzyos, when managing various medical conditions.
- As our understanding of genetics continues to grow, so too will our ability to predict and manage these interactions, ultimately leading to more personalized and effective treatments.
